教員

岡本 巌教授 / 博士(薬学)last update : 2022.04.02

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プロフィール

研究者名
岡本 巌(オカモト イワオ)
所属
薬品化学研究室
担当科目
有機化学概説(1年前期)
基礎有機化学Ⅰ(1年後期)
基礎有機化学Ⅱ(演習)(2年前期)
有機化学Ⅰ(演習)(2年後期)
有機化学実習Ⅱ(2年後期)
職位
教授
学位
博士(薬学)

学歴

1992年 3月 東京大学薬学部薬学科 卒業
1994年 3月 東京大学大学院薬学系研究科修士課程 修了
1997年 3月 東京大学大学院薬学系研究科博士課程 修了 博士(薬学)

 

経歴

1997年 4月 日本学術振興会特別研究員
1997年 6月 アメリカ合衆国,マサチューセッツ工科大学博士研究員(R. L. Danheiser教授)
1998年 4月 昭和薬科大学 薬化学研究室 助手
2001年 4月 同 講師
2007年 4月 同 准教授
2013年 4月 昭和薬科大学 薬品化学研究室 教授 現在に至る

 

免許?資格

  • 薬剤師
  • 危険物取扱者(甲種)

受賞歴

2008年 10月 日本薬学会関東支部奨励賞受賞

 

所属学協会

日本薬学会
基礎有機化学会
有機合成化学協会
アメリカ化学会

 

  • 原著論文 Structures and Reactivities of N-Alkenyl-Substituted Anilides: The “Magic” Methyl Effect on Alkene. Ryu Yamasaki, Mariko Ono, Kento Morita, Ai Ito, Kazuo Fukuda, Iwao Okamoto J. Org. Chem. 88 (20) 14487–14493 2023 
  • 原著論文 Synthesis and conformational analysis of N-aromatic acetamides bearing thiophene: effect of intramolecular chalcogen-chalcogen interaction on amide conformational stability. Ai Ito, Marino Asato, Yuki Asami, Kazuo Fukuda, Ryu Yamasaki, Iwao Okamoto J. Org. Chem. 88 (11) 7075–7087 2023 
  • 原著論文 Structure and Additive-free Transamidation of Planar N-Cyano Amides. Ryu Yamasaki, Yuko Okada, Hiromi Iizumi, Ai Ito, Kazuo Fukuda, Iwao Okamoto J. Org. Chem. 88 (9) 5704–5712 2023 
  • 原著論文 Reversible On/Off Conformational Switching of Pentafluorobenzoyl Amide Triggered by Acid Vapor and Sublimation Ryu Yamasaki, Misuzu Harada, Ai Ito, Kazuo Fukuda, Shota Matsumoto, Satoru Karasawa, Iwao Okamoto CrystEngComm 24 (35) 6226–6231 2022 
  • 原著論文 Conformational Switch of Benzanilide Derivative Induced by Acid; Effect of Pentafluorobenzoyl Group Ryu Yamasaki, Misuzu Harada, Rino Nagata, Ai Ito, Kazuo Fukuda, Iwao Okamoto J. Org. Chem. 87 (13) 8469–8479 2022 
  • 原著論文 Hybrid molecule between platanic acid and LCL-161 as a yes-associated protein degrader Naoko Nakano, Kazuo Fukuda, Etsu Tashiro, Haruka Ishikawa, Waka Nagano, Rie Kawamoto, Alice Mori, Misao Watanabe, Ryu Yamazaki, Takahisa Nakane, Mikihiko Naito, Iwao Okamoto, Susumu Itoh The Journal of Biochemistry 171 (6) 631–640 2022 
  • 原著論文 Synthesis and crystal structures of N,N-diarylacetamides bearing two azulene rings Ai Ito, Mayuko Watanabe, Ayako Ishii, Ryu Yamasaki, Iwao Okamoto Tetrahedron Lett. 86 Article 153523 2021 
  • 原著論文 Characterization of Push?Pull-Type Benzo[X]quinoline Derivatives (X = g or f): Environmentally Responsive Fluorescent Dyes with Multiple Functions Yasufumi Fuchi, Tomohiro Umeno, Yuichiro Abe, Keita Ikeno, Ryu Yamasaki, Iwao Okamoto, Kazuteru Usui, Satoru Karasawa J. Org. Chem. 85 13177–13190 2020 
  • 原著論文 Synthesis and conformational analysis of N-aryl-N-(6-azulenyl)acetamides Ai Ito, Ayako Ishii, Takamasa Amaki, Kazuo Fukuda, Ryu Yamasaki, Iwao Okamoto Tetrahedron Lett. 60 (29) 1929-1933 2019 
  • 原著論文 N-Ethynylation of Anilides Decreases the Double-Bond Character of Amide Bond while Retaining trans-Conformation and Planarity Ryu Yamasaki, Kento Morita, Hiromi Iizumi, Ai Ito, Kazuo Fukuda, Iwao Okamoto Chem. Eur. J. 25 (43) 10118-10122 2019 
  • 原著論文 Conformational analysis of N-aryl-N-(2-azulenyl)acetamides Ai Ito, Takamasa Amaki, Ayako Ishii, Kazuo Fukuda, Ryu Yamasaki, Iwao Okamoto Tetrahedron Lett. 59 (45) 3994-3998 2018 
  • 原著論文 Spontaneous and direct transformation of O-aryl-N-aryl carbamates into N,N’-diarylureas Ryu Yamasaki, Yutaka Honjo, Ai Ito, Kazuo Fukuda, Iwao Okamoto Chem. Pharm. Bull. 66 (9) 880-884 2018 
  • 原著論文 Synthesis and conformational analysis of N-aryl-N-(3-thienyl) acetamides Ai Ito, Yuki Asami, Marino Asato, Kazuo Fukuda, Ryu Yamasaki, Iwao Okamoto Tetrahedron Lett. 59 (25) 2454–2458 2018 
  • 原著論文 Crystal engineering of N,N'-diphenylurea compounds featuring phenyl-perfluorophenyl interaction Ryu Yamasaki, Mana Iida, Ai Ito, Kazuo Fukuda, Aya Tanatani, Hiroyuki Kagechika, Hyuma Masu, Iwao Okamoto Cryst. Crowth Des. 17 (11) 5858–5866 2017 
  • 原著論文 Acid-controlled switching of conformational preference of N,N-diarylamides bearing pyridine. Ai Ito, Hiroto Fujino, Keiko Ushiyama, Eriko Yamanaka, Ryu Yamasaki, Iwao Okamoto Tetrahedron Lett. 57 (42) 4737-4741 2016 
  • 原著論文 Gold-Catalyzed Synthesis of 2-Substituted Azepanes: Strategic Use of Soft Gold(I) and Hard Gold(III) Catalysts. Nobuyoshi Morita, Yuta Saito, Ayumi Muraji, Shintaro Ban, Yoshimitsu Hashimoto, Iwao Okamoto, Osamu Tamura Synlett 27 (13) 1936-1940 2016 
  • 原著論文 Gold-Catalyzed Dimeric Cyclization of Isoeugenol and Related 1-Phenylpropenes in Ionic Liquid: Environmentally Friendly and Stereoselective Synthesis of 1,2,3-Trisubstituted 2,3-Dihydro-1H-indenes. Nobuyoshi Morita, Rie Mashiko, Dai Hakuta, Daisuke Eguchi, Shintaro Ban, Yoshimitsu Hashimoto, Iwao Okamoto, Osamu Tamura Synthesis 48 (12) 1927-1933 2016 
  • 原著論文 Acid-induced molecular-structural transformation of N-methyl aromatic oligoamides bearing pyridine-2-carboxamide Ryu Yamasaki, Saori Fujikake, Ai Ito, Kentaro Migita, Nobuyoshi Morita, Osamu Tamura, and Iwao Okamoto Tetrahedron Lett. 57(1) 56-59 2016 
  • 原著論文 Acid- and base-induced conformational alternations of N-aryl-N-troponyl amides Ai Ito, Masanori Sato, Ryu Yamasaki, and Iwao Okamoto Tetrahedron Lett. 57(3) 438-441 2016 
  • 原著論文 BF3?Mediated cis-Selective Cycloaddition of O?Silyloxime with Alkenes Nobuyoshi Morita, Rina Kono, Kenji Fukui, Asuka Miyazawa, Hyuma Masu, Isao Azumaya, Shintaro Ban, Yoshimitsu Hashimoto, Iwao Okamoto, Osamu Tamura J. Org. Chem. 80 (9) 4797–4802 2015 
  • 原著論文 Gold(I)/(III)-Catalyzed Synthesis of Cyclic Ethers; Valency-Controlled Cyclization Modes Nobuyoshi Morita, Arisa Yasuda, Motohiro Shibata, Shintaro Ban, Yoshimitsu Hashimoto, Iwao Okamoto, Osamu Tamura Org. Lett. 17 (11) 2668–2671 2015 
  • 原著論文 Gold(I)/(III)-catalyzed synthesis of 2-substituted piperidines; valencycontrolled cyclization modes Nobuyoshi Morita, Tomonori Tsunokake, Yuji Narikiyo, Mayuka Harada, Tatsuyuki Tachibana, Yuta Saito, Shintaro Ban, Yoshimitsu Hashimoto, Iwao Okamoto, Osamu Tamura Tetrahedron Lett. 56 (45) 6269–6272 2015 
  • 原著論文 Solvent-dependent Conformational and Fluorescence Change of an N-Phenylbenzohydroxamic Acid Derivative Bearing Two Pyrene Moieties Misae Kanai, Tomoya Hirano, Isao Azumaya, Iwao Okamoto, Hiroyuki Kagechika, Aya Tanatani Tetrahedron 68 (13) 2778–2783 2012 
  • 原著論文 Redox-Responsive Conformational Alteration of Aromatic Amides Bearing N-Quinonyl System Iwao Okamoto, Yusuke Takahashi, Mika Sawamura, Mio Matsumura, Hyuma Masu, Kosuke Katagiri, Isao Azumaya, Masanori Nishino, Yukari Kohama, Nobuyoshi Morita, Osamu Tamura, Hiroyuki Kagechika, Aya Tanatani Tetrahedron 68 (27-28) 5346–5355 2012 
  • 原著論文 Synthesis and Biological Evaluation of Tubulysin D Analogues Related to Stereoisomers of Tubuvaline Taku Shibue, Iwao Okamoto, Nobuyoshi Morita, Hiroshi Morita, Yusuke Hirasawa, Takahiro Hosoya, Osamu Tamura Bioorg. Med. Chem. Lett. 21 (1) 431–434 2011 
  • 原著論文 Synthesis of the proposed structure of phaeosphaeride A Kenichi Kobayashi, Iwao Okamoto, Nobuyoshi Morita, Tamiko Kiyotani, Osamu Tamura Org. Biomol. Chem. 9 (16) 5825–5832 2011 
  • 原著論文 Stereoselective vinylogous Mannich reaction of 2-trimethylsilyloxyfuran with N-gulosyl nitrones Osamu Tamura, Kodai Takeda, NakaMita, Masanori Sakamoto, Iwao Okamoto, Nobuyoshi Morita, Hiroyuki Ishibashi Org. Biomol. Chem. 9 (21) 7411–7419 2011 
  • 原著論文 Convenient Synthesis of Aminopyridinecarboxylic Acids Iwao Okamoto, Masayuki Terashima, Rempei Yoshioka, Tomonori Muramatsu, Satomi Kojima, Haruka Inoue, Mio Takahashi, Nobuyoshi Morita, and Osamu Tamura Heterocycles 83 (10) 2343–2352 2011 
  • 原著論文 Acid-Induced Conformational Alteration of cis-Preferential Aromatic Amides Bearing N-Methyl-N-(2-pyridyl) Moiety Iwao Okamoto, Masayuki Terashima, Hyuma Masu, Mayumi Nabeta, Kaori Ono, Nobuyoshi Morita, Kosuke Katagiri, Isao Azumaya, Osamu Tamura Tetrahedron 67 (44) 8536–8543 2011 

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