Staff

Ai ItoSenior Assistant Professor / Ph.D.last update : 2022.12.27

Japanese

Profile

Name
Ai Ito
Affiliation
Laboratory of Pharmaceutical Organic Chemistry
Subjects
Fundamental Organic Chemistry 
Organic Chemistry
Official title
Senior Assistant Professor
Degree
Ph.D.
  • [Original paper] Structures and Reactivities of N-Alkenyl-Substituted Anilides: The “Magic” Methyl Effect on Alkene. Ryu Yamasaki, Mariko Ono, Kento Morita, Ai Ito, Kazuo Fukuda, Iwao Okamoto J. Org. Chem. 88 (20) 14487–14493 2023 
  • [Original paper] Synthesis and conformational analysis of N-aromatic acetamides bearing thiophene: effect of intramolecular chalcogen-chalcogen interaction on amide conformational stability. Ai Ito, Marino Asato, Yuki Asami, Kazuo Fukuda, Ryu Yamasaki, Iwao Okamoto J. Org. Chem. 88 (11) 7075–7087 2023 
  • [Original paper] Structure and Additive-free Transamidation of Planar N-Cyano Amides. Ryu Yamasaki, Yuko Okada, Hiromi Iizumi, Ai Ito, Kazuo Fukuda, Iwao Okamoto J. Org. Chem. 88 (9) 5704–5712 2023 
  • [Original paper]  Reversible On/Off Conformational Switching of Pentafluorobenzoyl Amide Triggered by Acid Vapor and Sublimation Ryu Yamasaki, Misuzu Harada, Ai Ito, Kazuo Fukuda, Shota Matsumoto, Satoru Karasawa, Iwao Okamoto CrystEngComm 24 (35) 6226–6231 2022 
  • [Original paper]  Conformational Switch of Benzanilide Derivative Induced by Acid; Effect of Pentafluorobenzoyl Group Ryu Yamasaki, Misuzu Harada, Rino Nagata, Ai Ito, Kazuo Fukuda, Iwao Okamoto The Journal of Organic Chemistry 87 (13) 8469–8479 2022 
  • [Original paper] Synthesis of Probe Molecules, 6-(Dimethylamino)-2-phenylisoindolin-1-ones, for Mechanistic Studies of Firefly Luciferase Inhibition Medha J. Gunaratna, Bo Hao, Man Zhang, Madoka Nakagomi, Ai Ito, Takeo Iwamoto, Duy H. Hua Heterocycles 103 (1) 231-248 2021 
  • [Original paper] Synthesis and crystal structures of N,N-diarylacetamides bearing two azulene rings Ai Ito, Mayuko Watanabe, Ayako Ishii, Ryu Yamasaki, Iwao Okamoto Tetrahedron Letters 86 Article 153523 2021 
  • [Original paper]  Synthesis and conformational analysis of N-aryl-N-(6-azulenyl)acetamides Ai Ito, Ayako Ishii, Takamasa Amaki, Kazuo Fukuda, Ryu Yamasaki, Iwao Okamoto Tetrahedron Lett.  60 (29) 1929-1933 2019 
  • [Original paper]  N-Ethynylation of Anilides Decreases the Double-Bond Character of Amide Bond while Retaining trans-Conformation and Planarity Ryu Yamasaki, Kento Morita, Hiromi Iizumi, Ai Ito, Kazuo Fukuda, Iwao Okamoto Chem. Eur. J. 25 (43) 10118-10122 2019 
  • [Original paper]  Conformational analysis of N-aryl-N-(2-azulenyl)acetamides Ai Ito, Takamasa Amaki, Ayako Ishii, Kazuo Fukuda, Ryu Yamasaki, Iwao Okamoto Tetrahedron Lett. 59 (45) 3994-3998 2018 
  • [Original paper]  Spontaneous and direct transformation of O-aryl-N-aryl carbamates into N,N'-diarylureas Ryu Yamasaki, Yutaka Honjo, Ai Ito, Kazuo Fukuda, Iwao Okamoto Chem. Pharm. Bull. 66 (9) 880-884 2018 
  • [Original paper]  Synthesis and conformational analysis of N-aryl-N-(3-thienyl) acetamides Ai Ito, Yuki Asami, Marino Asato, Kazuo Fukuda, Ryu Yamasaki, Iwao Okamoto Tetrahedron Lett. 59 (25) 2454–2458 2018 
  • [Original paper]  Crystal engineering of N,N'-diphenylurea compounds featuring phenyl-perfluorophenyl interaction  Ryu Yamasaki, Mana Iida, Ai Ito, Kazuo Fukuda, Aya Tanatani, Hiroyuki Kagechika, Hyuma Masu, Iwao Okamoto Cryst. Crowth Des. 17 (11) 5858–5866 2017 
  • [Original paper]  Acid-controlled switching of conformational preference of N,N,-diarylamides bearing pyridine. Ai Ito, Hiroto Fujino, Keiko Ushiyama, Eriko Yamanaka, Ryu Yamasaki, Iwao Okamoto Tetrahedron Lett. 57 (42) 4737-4741 2016 
  • [Original paper] Acid-induced molecular-structural transformation of -methyl aromatic oligoamides bearing pyridine-2-carboxamide Ryu Yamasaki, Saori Fujikake, Ai Ito, Kentaro Migita, Nobuyoshi Morita, Osamu Tamura, and Iwao Okamoto Tetrahedron Lett. 57(1) 56-59 2016 
  • [Original paper] Acid- and base-induced conformational alternations of -aryl--troponyl amides Ai Ito, Masanori Sato, Ryu Yamasaki, and Iwao Okamoto  Tetrahedron Lett. 57(3) 438-441 2016 
  • [Original paper] Silicon-Containing GABA Derivatives, Silagaba Compounds, as Orally Effective Agents for Treating Neuropathic Pain without Central-Nervous-System-Related Side Effects Hiroshi Fukasawa, Hideaki Muratake, Ai Ito, Hideyuki Suzuki, Yohei Amano, Marina Nagae, Kiyoshi Sugiyama and Koichi Shudo ACS Chem Neurosci. 5(7) 525-532 2014 
  • [Original paper] Deprotonation Equilibrium of 5-Tropolonediazonium Salt Strongly Favors 1,2,5-Tropoquinone-5-diazide Structure in Certain Solvents. Ai Ito, Hideaki Muratake, and Koichi Shudo J. Org. Chem. 78(11) 5470-5475 2013 
  • [Original paper] A Novel Aromatic Carboxylic Acid Inactivates Luciferase by Acylation of an Enzymatically Active Regulatory Lysine Residue. Madoka Nakagomi, Nobuko Fujimaki, Ai Ito, Takahiro Toda, Hiroshi Fukasawa, Koichi Shudo, Ryoichi Tomita  PLoS ONE 8(9) e75445 2013 
  • [Original paper] (R)- and (S)-4-Amino-3-(trimethylsilyl)methylbutanoic Acids Ameliorate Neuropathic Pain without Central Nervous System-related Side Effects. Hideaki Muratake, Ai Ito, Takahiro Toda, Hideyuki Suzuki,Hiroshi Fukasawa, Makoto Tsuda, Kazuhide Inoue, Koichi Shudo Bioorg. Med. Chem. Lett.  22(24) 7602-7604 2012 

Conference, etc.

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  • [Poster presentation] フェニル-パーフルオロフェニル相互作用を利用したウレア、アミド化合物の構造解析 飯田 愛菜, 永田 理乃, 山﨑 龍, 伊藤 愛, 枡 飛雄真, 棚谷 綾, 影近 弘之, 岡本 巌 日本薬学会第136年会 横浜 2016/03/26?2016/03/29
  • [Poster presentation] ピリミジンを有するN-アルキルピリジン-2,6-ジカルボン酸アミドの不斉結晶化 濱松 朱音, 伊藤 愛, 佐久間 優子, 廣瀬 良嗣, 山﨑 龍, 桝 飛雄真, 東屋 功, 岡本 巌 日本薬学会第136年会 横浜 2016/03/26?2016/03/29
  • [Poster presentation] Control of molecular arrangement mediated by the interaction between benzene-perflfluorobenzene Yamasaki R, Iida M, Nagata R, Ito A, Tanatani A, Kagechika, H, Okamoto I. 2015 環太平洋国際化学会議 ホノルル 2015/12/15?2015/12/20
  • [Poster presentation] 水素結合とフェニルーパーフルオロフェニル相互作用を利用した分子配列ー配向制御 山﨑 龍, 飯田 愛菜, 永田 理乃, 伊藤 愛, 桝 飛雄真, 棚谷 綾, 影近 弘之, 岡本 巌 第41回反応と合成の進歩シンポ 吹田 2015/10/26?2015/10/27
  • [Poster presentation] 大環状N-アルキルピリジルアミド三量体をホスト分子とした共結晶化 伊藤 愛, 児玉 大樹, 張谷 香奈恵, 小島 絵美, 山﨑 龍, 桝 飛雄真, 東屋 功, 岡本 巌 第26回基礎有機化学討論会 松山 2015/09/24?2015/09/26
  • [Poster presentation] ?アルキルニコチン酸アミドとm-ハロピリジンとのカップリング反応による3,5?置換型ピリジン含有アミドの合成と構造解析 志村 佳恵, 張谷 香奈恵, 伊藤 愛, 山﨑 龍, 岡本 巌 日本薬学会関東支部 船橋 2015/09/12
  • [Poster presentation] Acid- and base induced conformational alternation of N,N-diarylamides bearing tropolone Ito A, Sato M, Yamasaki R, Okamoto I. 250th ACS National Meeting & Exposition ボストン 2015/08/16?2015/08/20
  • [Poster presentation] pH Dependent molecular folding and unfolding of macrocyclic N-alkyl pyridinecarboxamides Hariya K, Kojima E, Yoshioka R, Ito A, Yamasaki R, Okamoto I. 10th ISMSC 2015 ストラスブルグ 2015/06/28?2015/07/2
  • [Oral presentation] 5-トロホ?ロンシ?アソ?ニウム塩の脱フ?ロトン化平衡を利用した新規カルヘ?ン前駆体の合成と特性 伊藤 愛, 山﨑 龍, 岡本 巌 日本薬学会第135年会 神戸 2015/03/25?2015/03/27
  • [Oral presentation] N-アリール-N-トロホ?ニル型芳香族アミト?の立体構造特性と酸塩基応答型の構造変換 佐藤 正規, 伊藤 愛, 山﨑 龍, 岡本 巌 日本薬学会第135年会 神戸 2015/03/25?2015/03/27
  • [Poster presentation] 酸化還元応答型N-メチル芳香族アミドの立体構造特性と配座変換 伊藤 愛, 渋谷 恵祐, 山﨑 龍, 岡本 巌 第58回日本薬学会関東支部会 町田 2014/10/04
  • [Poster presentation] N-ヒ?リシ?ル型およひ? N-トロホ?ニル型芳香族アミト?の立体構造特性と構造変換 佐藤 正規, 伊藤 愛, 藤野 大人, 山﨑 龍, 岡本 巌  第44回複素環化学討論会 札幌 2014/09/10?2014/09/12
  • [Poster presentation] Conformational preferences and alteration of N,N-diaryl amides bearing tropolone and pyridine. Ai Ito, Masanori Sato, Hiroto Fujino, Iwao Okamoto 248th ACS National Meeting & Exposition サンフランシスコ 2014/08/09?2014/08/14
  • [Poster presentation] Acid-induced folding of aromatic N-methyl amides bearing pyridine-2-carboxylic amides. Saori Fujikake, Ai Ito, Masayuki Terashima, Iwao Okamoto 248th ACS National Meeting & Exposition サンフランシスコ 2014/08/09?2014/08/14

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